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Company / Organization
Radboud University Nijmegen
Title / Position
Professor of Mechanisms of Inflammatory Diseases
Leo Joosten was born in Gendt and studied pathobiology in Nijmegen, The Netherlands. He completed his PhD at the Radboud University Nijmegen, The Netherlands, on studies investigating the role of cytokine targeting in arthritis. After 25 years of research in Rheumatology, he started as head of the research laboratory experimental medicine, Department of Internal Medicine, Nijmegen University Nijmegen Medical Center. He is mainly interested in understanding pathways that are involved in the transition of infection to autoinflammatory or autoimmune diseases. In addition, the variability of human immune responses towards pathogens is one of his research fields.
His group coordinates the Human Functional Genomics Project which, during the last couple of years, has described the genetic, epigenetic and microbiome factors that influence human physiological responses to infection and Inflammation. With focus on Lyme disease and gout.
Topic of speech
Functional genomic architecture of Borrelia burgdorferi-induced cytokine responses in humans.